The Pharmacy department at KLEF has identified the following thrust areas for research which are in line with the interest of our Nation and WHO on public health and diseases.

S.No.	Faculty Name	Specialization	Thrust Areas for Research & Development
1	Dr.Subhranshu Panda	Pharmaceutics	·         Herbal formulations ·         Novel drug delivery ·         Preclinical trials ·         Cosmetics & nutraceuticals
2	Dr. G. Chakaravarthi	Pharmacognosy and Phytochemical Analysis	·         Natural products based drug discovery for infectious diseases and cancer
3	Dr. K. Uma Sankar	Pharmaceutical Chemistry	·         Synthesis of novel organic compounds ·         Isolation and evaluation of active principles from plant extracts ·         Molecular docking methods
4	Dr.Siva Prasad Panda	Pharmacology & Toxicology	·         Isolation of phytoconstituents from natural sources with the help of chromatographic techniques ·         Acute toxicity studies (OECD guidelines), developmental toxicity on zebrafish model ·         In vivo (rat model) and in vitro (a-amylase and a-glycosidase inhibitory assay) antidiabetic studies ·         Anticancer, antimicrobial, hepatoprotective activity studies
5	Dr. G.S.N. Koteswara Rao	Pharmaceutics	·         Development and biopharmaceutical evaluation of controlled release systems ·         Design, development and evaluation of novel drug delivery systems like liposomes and naoparticles ·         Physico-chemical characterization of novel polymers ·         DoE, factorial design based studies, statistical analysis
6	Dr. D. Damayanthi	Pharmacology	·         Preclinical studies ·         Pharmacokinetic and pharmacodynamic studies
7	Dr.Uttam Prasad Panigrahy	Pharmaceutical Analysis and Quality Assurance	·         Analytical chemistry ·         Bioanalytical method development ·         Drug stability studies ·         Impurity profiling studies
8	Mr.A.Rajasekhar Reddy	Pharmaceutical Chemistry	·         Small molecules synthesis ·         Molecular modeling ·         Isolation of phytoconstituents from plants and extraction of biological activities
9	Mr.G.Kalyani	Pharmacology	·         Toxicology studies ·         Drug screening methods ·         Animal model based kinetic and dynamic profiling of drug
10	Mr.K.Venkata Gopaiah	Pharmaceutics	·         Nanosuspensions formulation and evaluation ·         Targeted drug delivery systems
11	Ms. N. Sri Lakshmi	Pharmaceutical Chemistry	·         Pharmaceutical organic chemistry ·         Medicinal chemistry ·         Pharmacognostic and phytochemistry works

Beside the R&D focus, the faculty at the KLEF Pharmacy department possess unique skills and knowledge in organic synthesis, bulk drugs and quality control for Active Pharmaceutical Ingredients (API). The department is able to offer the following consultancy services to the pharmaceutical and health care industries.

S.No	Faculty Name	Specialized areas for consultancy service to Industry
1	Dr. Subhranshu Panda	1) Design and development of novel drug delivery systems2) Formulation and evaluation of sustained release systems
2	Dr. K. Uma Sankar	1) Docking studies.2) Synthesis and evaluation of new organic compounds
3	Dr. Siva Prasad Panda	1) Alternative animal studies for various activities2) Isolation and activity profiling
4	Dr. G.S.N. Koteswara Rao	1) DoE based studies in formulation design for optimization2) Formulation, in vitro and in vivo evaluation of controlled release systems
5	Mr. A.Rajasekhar Reddy	1) Design and synthesis of organic molecules.2) Purification and structure analysis.

Dr. G. Chakravarthi

1. Guntupalli Chakravarthi, Alavala Rajasekhar Reddy, Maddi Ramayya, Assessment of Biological Activity and Comparison of UPLC and RP-HPLC Chromatographic Profles of Clausena excavata Burm.F. Pharmacogn J. 2017; 9(1): 98-101.

Dr. Suresh B. Vepuri

1. Payal Narang, Suresh B Vepuri, Pannuru Venkatesu and Mahmoud E Soliman. (2017). An unexplored remarkable PNIPAM-osmolyte interaction study: An integrated experimental and simulation approach. Journal of Colloid and Interface Science (In Press). (IF-3.78). https://doi.org/10.1016/j.jcis.2017.05.109

2. Reddicherla Umapathi, Suresh B Vepuri, Pannuru Venkatesu and Mahmoud E Soliman. (2017). Comprehensive Computational and Experimental Analysis of Biomaterial towards the Behavior of Imidazolium-based Ionic Liquids: An Interplay between Hydrophilic and Hydrophobic Interactions. Journal of Physical Chemistry B 121 (18), pp 4909–4922. http://doi.org/10.1021/acs.jpcb.7b02208

3. S Ahmed, SB Vepuri, M Jadhav, RS Kalhapure, T Govender. (2017). Identifying the Interaction of Vancomycin With Novel pH-Responsive Lipids as Antibacterial Biomaterials Via Accelerated Molecular Dynamics and Binding Free Energy Calculations. Cell Biochemistry and Biophysics, 1-13 (In Press). http://doi.org/10.1007/s12013-017-0786-5

4. Ellen, M., Jadhav, M., Chunderika, M., Vepuri, S.B., Kalhapure, R.S., Soliman, M.E. & Govender, T. (2017). Preparation and Optimization of Meropenem Loaded Solid Lipid Nanoparticles:In vitro Evaluation and Molecular Modeling. AAPS PharmSciTech (In Press) http://doi.org/10.1208/s12249-016-0675-z

5. Sonawane, S. J., Kalhapure, R. S., Rambharose, S., Mocktar, C., Vepuri, S. B., Soliman, M., & Govender, T. (2016). Ultra-small lipid-dendrimer hybrid nanoparticles as a promising strategy for antibiotic delivery : In vitro and in silico studies. International Journal of Pharmaceutics, 504(1-2), 1–10. http://doi.org/10.1016/j.ijpharm.2016.03.021

6. Sikwal, D. R., Kalhapure, R. S., Rambharose, S., Vepuri, S., Soliman, M., Mocktar, C., & Govender, T. (2016). Polyelectrolyte complex of vancomycin as a nanoantibiotic : Preparation , in vitro and in silico studies. Materials Science & Engineering C, 63, 489–498. http://doi.org/10.1016/j.msec.2016.03.019

7. Ahmed, S., Vepuri, S. B., Kalhapure, R., & Govender T. Interactions of Dendrimers with Biological Drug Targets: Reality or Mystery - A Gap in Drug Delivery and Development Research. Biomatertials Science, 4, 1032-1050. http://doi.org/10.1039/C6BM00090H

8. Ahmed, S., Vepuri, S. B., Ramesh, M., Kalhapure, R., Suleman, N., & Govender, T. (2016). In Silico Characterization of the Binding Affinity of Dendrimers to Penicillin-Binding Proteins (PBPs): Can PBPs be Potential Targets for Antibacterial Dendrimers? Applied Biochemistry and Biotechnology 178(8), 1546-1566. http://doi.org/10.1007/s12010-015-1967-6

9. Seedat, N., Kalhapure, R. S., Mocktar, C., Vepuri, S., Jadhav, M., Soliman, M., & Govender, T. (2016). Co-encapsulation of multi-lipids and polymers enhances the performance of vancomycin in lipid-polymer hybrid nanoparticles: In vitro and in silico studies. Materials Science and Engineering C, 61, 616–630. http://doi.org/10.1016/j.msec.2015.12.053

10. Ramesh, M., Vepuri, S. B., & Oosthuizen, F. (2016). Adenosine Monophosphate-Activated Protein Kinase ( AMPK ) as a Diverse Therapeutic Target : A Computational Perspective. Applied Biochemistry and Biotechnology 178(4), 810–830. http://doi.org/10.1007/s12010-015-1911-9.

11. Vepuri, S. B., Devarajegowda, H. C., & Soliman, M. E. (2016). Synthesis, Characterization and Molecular modelling of a Novel Dipyridamole Supramolecule- X-ray Structure, Quantum Mechanics and Molecular Dynamics study to comprehend the Hydrogen Bond Structure - Activity relationship. Journal of Molecular Structure, 1105, 194-204. http://doi.org/10.1016/j.molstruc.2015.10.050

12. Vepuri, S. B., & Anbazhagan, S. (2013). A review on supramolecular chemistry in drug design and formulation research. Indonesian Journal of Pharmacy, 24(3), 131–150. http://doi.org/10.14499/ indonesianjpharm0iss0pp131-150

13. B Vepuri, S., Anbazhagan, S., P, N., & Divya, D. (2012). Pharmacophore Modeling and Docking Based QSAR Studies of Aryl Amidino Isoxazoline Derivatives to Design Potential FXa Inhibitors. American Journal of Bioinformatics Research, 2(3), 11–20. http://doi.org/10.5923/j.bioinformatics.20120203.01

14. Vepuri, S. B., Anbazhagan, S., & Lavanya, K. (2012). Insilico Binding Evaluation of Solid State Structures of Few Bromo Substituted Aryl Chalcones - Structure Based Lead Identification for Human Aldose Reductase Inhibition. Der Pharmacia Lettre, 4(3), 747–754

15. Vepuri, S. B., Anbazhagan, S., & Prasad, Y. R. (2012). Human Aldose Reductase Inhibition By (2E) -1- (5-bromothiophen-2-yl) -3- (2-bromophenyl) prop-2-en-1-one – Structure Based Lead Identification By Induced Fit Docking (IFD) Study of the Ligand Crystal Structure Conformation International Journal of Drug Design and Discovery, 3(4), 955–963.

16. Vepuri, S. B., Devarajegowda, H. C., Anbazhagan, S., & Prasad, Y. R. (2012). Induced Fit Docking ( IFD ) Study of the Solid State Structure of (2E) -1- (5- Fragment Based Design Approach for Human Aldose Reductase Inhibition. Letters in Drug Design and Discovery, 9(8), 789-796. http://doi.org/10.2174/157018012802652949

17. Vepuri, S. B., Devarajegowda, H. C., Jeyaseelan, S., Anbazhagan, S., & Prasad, Y. R. (2012). (2E)-3-(2-Bromo-phen-yl)-1-(5-bromo-thio-phen-2-yl)prop-2-en-1-one. Acta Crystallographica. Section E, Structure Reports Online, 68(Pt 12), o3456. http://doi.org/10.1107/S1600536812047939

18. Vepuri, S. B., Devarajegowda, H. C., Al-Eryani, W. F. A., Lavanya, K., & Anbazhagan, S. (2011). (E)-1-(5-Bromo-thio-phen-2-yl)-3-(3,4,5-trimeth-oxy-phen-yl)prop-2-en-1-one. Acta Crystallographica. Section E, 67(Pt 12), o3474. http://doi.org/10.1107/S1600536811049294

19. Vepuri, S. B., Tawari, N. R., & Degani, M. S. (2007). Quantitative Structure–Activity Relationship Study of Some Aspartic Acid Analogues to Correlate and Predict their Sweetness Potency. QSAR & Combinatorial Science, 26(2), 204–214. http://doi.org/10.1002/qsar.200530191

Dr. K. Uma Sankar

1. Muthukumar K, Manojkumar M, Samiye Y, Gulberk U, Sinha BN, Arijit B, Nibha M, Ashoke S, Umasankar K, Venkatesan J, Development of selective and reversible pyrazoline based MAO-A inhibitors: Synthesis, biological evaluation and docking studies, Bioorganic & Medicinal Chemistry, 18, 1875-1881 (2010) (Impact Factor: 3.157)

2. Shireesha B, Umasankar K, Srinivas S, Reddy VM, Synthesis, Antimicrobial evaluation and Docking studies of novel 4-Quinazolinyl heterocyclics as DNA-gyrase inhibitors, Archiv Der Pharmazie 10, 570–576, (2010) (Impact Factor: 1.708)

3. Umasankar K, Valisakka Gari P, Kyatham S, Shireesha B, Vidyasagar JV, Rao TR, Jayaveera KN, Arijit B, Venkatesan J, Synthesis, Antimicrobial and Anticancer Activity of New Thiosemicarbazone Derivatives. Archiv Der Pharmazie 344, 84–90, (2011). (Impact Factor: 1.708)

4. Sirisha K, Chandrashekhar M, Umasankar K, Mahendar P, Sadanandam A, Achaiah G, Reddy VM, Molecular Docking Studies and in-vitro Screening of New Dihydropyridine Derivatives as Human MRP1 inhibitors. Bioorganic & Medicinal Chemistry. 19(10): 3249-3254 (2011). (Impact Factor: 3.157)

5. Mahendar P, Sirisha K, Umasankar K, Shankar P, Sadanandam A. In silico evaluation of TERT inhibition by anticancer drugs. Journal of Molecular Modeling 18, 2012, 4739-4744 (Impact Factor: 1.871)

6. Dinesh P, Ramesh A, Prabahar SA, Reddy AR, Umasankar K, Shireesha B, Solid Phase Microwave assisted synthesis of Curcumine Analogs, Letter in Organic Chemistry 2012, 9, 447-450 (Impact Factor: 0.822)

7. Prabahar SA, Reddy AR, Umasankar K, Shireesah B Kundan I, Two dimensional quantitative structure activity relationship (2d-QSAR) studies of Tacrine analogs for Acetyl choline esterase (AChE inhibition) using Multiple linier multiple linear regression analysis. Letters in Drug Design & Discovery. 2012, 9, 858-866 (Impact Factor: 0.872)

8. Umasankar K, Shireesha B, Mahesh Ch, Vidyasagar JV, Rao TR, Jayaveera KN, Philipp S, Geraldine G, Thomas S, Venkatesan J, Synthesis, Antimicrobial and Anticancer Activity of N'-arylmethylidene-piperazine-1-carbothiohydrazide. Medicinal Chemistry Research. 2013, 22, 2802–2808. (Accepted; Impact Factor: 1.271)

9. Manojkumar M, Umasankar K, Philipp S, Geraldine G, Thomas S, Graciela A, Robert S, Jan B, Venkatesan J, Methyl-2-arylidene hydrazine-carbodithioates: synthesis and biological activity, Chemical Papers, 2013, 67(6), 650-656. (Impact Factor: 1.096)

10. Reddy AR, Dinesh P, Prabhakar AS, Umasankar K, Shireesha B, Raju MB. A comprehensive review on SAR of Curcumin, Mini-Review in Medicinal Chemistry 13(12):1769-77. 2013. (Impact Factor: 2.921)

11. Umasankar K, Manasa CL, Surender JS, Rao TR, Jayaveera KN, Shreesha B, Alexander- Thomas H, Johanna S, Martin M, Christophe R, Manfred J, Venkatesan J. Hydroxamates of para-Aminobenzoic acid as selective inhibitors of HDAC8. Bioorganic Chemistry, 2014, 57, 116-120. (Impact Factor: 2.14)

12. Narender M, Jaswanth SB, Umasankar K, Malathi J, Raghuram Reddy A, Umadevi KR, Dusthackeer AVN, Venkat Rao K, Rao AR. Synthesis, in vitro antimycobacterial evaluation and docking studies of some new 5,6,7,8-tetrahydropyrido[4’,3’:4,5]thieno[2,3-d]pyrimidin-4(3H)-one schiff bases. Bioorganic & Medicinal Chemistry Letters. 2016, 26:836-840. (Impact Factor: 2.40)

13. Narender M, Umasankar K, Malathi J, Shravan Kumar G, Rao AR. Synthesis, Antimycobacterial Evaluation and Docking Studies of some 7-Methyl-5,6,7,8- tetrahydropyrido[4',3':4,5]thieno[2,3-d]pyrimidin-4(3H)-ones. Chemical and Pharmaceutical Bulletin. Accepted for Publication, Article No: c17-00999). (Impact Factor: 1.258)

14. Rajasekhar RA, Umasankar K, Pochaiah B, Shireesha B, Venkatesan J, Ananda TS. Synthesis and Antiviral Activity of Dihydropyrimidines - Ciprofloxacin Mannich bases Against Various Viral Strains. Anti-Infective Agents, 2015, 13: 154-165.

15. Shireesha B, Umasankar K, Rao AR, Rajan KS, Raghuprasad M, Design, Synthesis and H1- Antagonistic activity of novel thieno[2,3-d] pyrimidinones, International Journal of Pharmaceutical Sciences and Nanotechnology, 1(2), 136-143 (2008).

16. Lalitha KG, Venkatachalam T, Srinivasan R, Kalaiselvi P, Umasankar K, A New Analytical Method Development and Validation for the Simultaneous Estimation of Ramipril, Atorvastatin and Clopidogrel in Capsule Dosage Form By RP-HPLC, Journal of Pharmacy and Chemistry, 3(3), (2009).

17. Babu GS, Rajani N, Malathy PS, Srinivas B, Umasankar K, Rao JV, Synthesis, Characterization and Evaluation of Novel N-(1H-Benzimidazol-2-Yl)-2-Isatinylidene-Hydrazine-carboxamide Derivatives as Anti-Inflammatory Agents. Der Pharma Chemica, 2(3):196-204 (2010)

18. Suresh V, Kumar VM, Suresh A, Kumar NS, Arunachalam G, Umasankar K, CNS activity of ethanol extract of Wedelia chinensis in experimental animals, International Journal of Pharmaceutical Sciences and Nanotechnology, 3: 881-886 ( 2010)

19. Babu GS, Swathy T, Malathy PS, Srinivas B, Umasankar K, Rao JV, Raghunandan N. Synthesis, Characterization and Evaluation of Novel substituted benzo-indolylidene acetohydrazide Derivatives as Anti-Microbial Agents, Der Pharmacia Letter, 2(4): 408-415, (2010).

20. Thangadurai SA, Maninder M, Sharad W, Shyam A, Umasankar K, Narasimhan B, Biological values of the Heterocyclic compounds Quinazoline, Acta Pharmaceutica Sciencia. 53: 347-361 (2011).

21. Srujana M, Jyothi B, Mahesh Ch, Reddy MS, Umasankar K, Reddy VM, Synthesis And Pharmacological Evaluation Of Novel Mannich Bases Of Quinazolines. Scientific Journal of Pharmacy 1:30-37 (2011).

22. Venkateshwarlu E, Rao JV, Umasankar K, Dheeraj G, Study of Antiinflam-matory, Analgesic and Antipyretic Activity of Novel Isatin Derivatives, Asian Journal of Pharmaceutical and Clinical Research, 2012, 5, 187-190.

23. Venkateshwarlu E, Umasankar K, Bhava BSS, Rao JV. Screening of the Anticonvulsant Activity of Some Isatin Derivatives in Experimental Seizure Models and Its Effect on Brain GABA Levels in Mice. American Journal of Pharmacological Sciences 2013:1(3): 42-46.

24. Venkateshwarlu E, Bhava BSS, Umasankar K, Rao JV. Evaluation of Diuretic Activity of Isatin Derivatives in Wistar Rats. Journal of Pharmacy and Nutrition Sciences 2013:3:141-148.

25. Subrahmanyam BS, Bhava BSS, Venkateshwarlu E, Umasankar K, Dileep P, Murthy SV. Efficacy of Oral Anti-Diabetic Agents for Glycemic Control inType-2 Diabetic Patients with Obesity.Global Journal of Pharmacology 2013:7(3): 311-315.

26. Grija P, Bhava BSS, Venkateshwarlu E, Umasankar K, Rao JV. Anti-arthritic activity of ethanolic extract from the leaves of Commiphora caudata (Linn.) in complete freund's adjuvant induced arthritic rats. Nigerian Journal of Experimental and Clinical Biosciences. 2014, 2, 42-48.

27. Umasankar K, Bhawatha Ch, Shireesha B, Reddy AR. Synthesis Antimicro-bial and Anticancer Activity of 1-[(arylalkylidene)amino]-3-(4H-1, 2, 4-triazol-4-yl)thiourea. Journal of Pharmaceutical Chemistry, 2014, 1, 5-9.

28. Venkateshwarlu E, Swathi G, Bhava BSS, Kumar RS, Rao JV, Umasankar K, Evaluation of Anticancer Activity of Annona muricata in 1, 2-Dimethyl Hydrazine Induced Colon Cancer. World Applied Sciences Journal . 2014: 32(3): 444-450.

29. Arvind P, Reddy KS, Bhava BSS, Umasankar K, Venkateshwarlu E, Rao JV. Investigation of lipid profile and occular oxidative stress of Chloroxylon swieteniaon Streptozotocinnicotinamideinduced diabetic rats. Inter-national Journal of Green Pharmacy 2014:8(2):90-96.

30. Rao JV, Venkateshwarlu E, Bhava BSS, Umasankar K, Synthesis and evaluation of neuropharmacological profile of isatin-3-[N2-(2-benzal-aminothiazol-4-yl)] hydrazones. Egyptian Pharmaceutical Journal 2014:14 (2):130-138

31. Umasankar K, Srikanth Ch, Reddy AR, Gomathi P, Shireesha B. Synthesis, Antiglycating and Antioxidant activities of Triazolo hexahydro-quinazolines. Journal of Pharmaceutical Chemistry 2014:2:6-11

32. Venkateshwarlu E, Bhava BSS, Kumar RS, Rao JV, Gouthami E, Umasankar K; Evaluation of diuretic activity of Syzygium cumini and its effect on prostaglandin system. Orient Pharmacy and Experimental Medicine 2015:15:45-51.

33. Venkateshwarlu E, Bhava BSS, Bharadwaj SA, Kumar RS, Umasankar K, Rao JV. Evaluation of diuretic and antidiabetic activity of esculin in wistar rats. International Journal of Pharmacy and Biological Sciences 2015:5:267-276

34. Venkateshwarlu E, Bhava BSS, Adukondalu D, Nagarani D, Umasankar K, Kumar RS, Reddy KS, Effect of Atorvastatin on Pharmacology of Sitagliptin in Streptozotocin- Nicotinamide induced Type-II diabetes in rats Biology and Medicine 2015: 7:1-4

35. Venkateshwarlu E, Bhava BSS, Pavani S, Shiva Kumar R, Umasankar K, Suresh Reddy G. Pharmacokinetic and Pharmacodynamic interaction between Simvastatin and Diltiazem in rats with induced hyper-cholesterolaemia and hypertension. Formulation Development and Analysis. DOI: http://dx.doi.org/10.14805/fda.201512.%25p

36. Venkateshwarlu E, Umasankar K, Sharvana Bhava BS, Venkateshwar Rao J Evaluation of Antioxidant, Antimicrobial and Anticancer activity of Thiazole Tagged Isatin Hydrazones. Journal of Pharmaceutical Chemistry. 2016, 3, 4-9

37. Reddy ARR, Prathusha K, Ganapathi T, Umasankar K, Shireesha B, Raju MB. Study of in vivo pharmacokinetic drug interactions of curcumin on tacrine. Asian Journal of Pharmaceutical and Clinical Research, 2018, 11, 1-7.

Dr. Siva Prasad Panda

1. Siva Prasad Panda, Bikash Ranjan Jena, Uttam Prasad Panigrahy. Overexpressed CYP450 mediated apoptosis evaluates cytotoxicity and teratotoxicity of Cucumis callosus. Oriental Pharmacy and Experimental Medicine. (OPEM-Springer). (https://doi.org/10.1007/s13596-018-0324-z) December 2018; 18(4).

2. Siva Prasad Panda, Asit Kumar Sarangi, Uttam Prasad Panigrahy. Isolation of Cucurbitacin-B from Cucumis callosus and its hypoglycemic effect in isolated rat enterocytes. International J of Pharmacy and Pharmaceutical Sciences (IJPPS) 2018; 10 (5): 123-129. DOI: http://dx.doi.org/10.22159/ijpps.2018v10i5.25788. [SCI IF-0.50].

3. Siva Prasad Panda, A Rajsekhar Reddy, Uttam Prasad Panigrahy. Evaluation of anticancer activity of Cucumis callosus against Ehrlich’s Ascites Carcinoma bearing mice. Asian Journal Pharmaceutical and Clinical Research (AJPCR) 2018. DOI: http://dx.doi.org/10.22159/ajpcr.2018.v11i10.27439, October 2018; 11(10). [SCI IF-0.40]

4. Uttam Prasad Panigrahy, Siva Prasad Panda and Muvvala Sudhakar. Colorimetric analysis of Raltegravir in pharmaceutical formulation and human biological fluids through oxidative coupling reaction using 3-methyl-2-benzothiazolinone hydrazone reagent. 2018. Research Journal of Pharmacy and Technology. 2018; 11(5). [SCI IF 0.16]

5. Siva Prasad Panda, Mainak Chakraborty, Poulami Majumder, Suchandra Mazumder, Sudipta Das, Pallab Kanti Haldar*. “Antidiabetic, antioxidant and anti-hyperlipidaemic activity of Cucumis callosus in streptozotocin-induced diabetic rats. International Journal of Pharmaceutical Science and Research (IJPSR) 2016; 7(5): 1978-1984. [SCI IF-2.60]

6. Siva Prasad Panda, Pallab K Haldar*, Sudipta Das. In vitro hypoglycemic and antimicrobial activity of Cucumis callosus (Rottl.) Cogn. fruit. Asian Journal Pharmaceutical and Clinical Research (AJPCR) 2016; 9(2): 77-81. [IF-0.40]

7. Siva Prasad Panda, Mainak Chakraborty, Poulami Majumder, Suchandra Mazumder, Sudipta Das, Pallab Kanti Haldar*. Hepatoprotective Efficacy of Cucumis callosus (Rottl.) cogn. (Cucubitaceae) fruit against CCl4-induced Hepatic Damage in Rats. International Journal of Phytopharmacology (IJP) 2016; 7(4): 218-223. [IF-1.02]

8. Siva Prasad Panda, Nilanjan Sarkar, Sudipta Das, Asis Bala and Pallab Kanti Haldar*. Evaluation of Analgesic and Anti-inflammatory Activity of Methanol Extract of Cucumis callosus roots in Animal Models. Pharmacologia 2016; 7 (5): 283-289.

9. Siva Prasad Panda, PK Haldar, S Bera, S. Adhikary, C.C. Kandar “Antidiabetic and antioxidant activity of Swietenia mahagoni in streptozotocin-induced diabetic rats” Pharmaceutical Biology, USA 2010; 48(9): 974-979. [IF-1.91]

10. Siva P. Panda, S. Bera, S. Adhikary, C. C. Kandar, P. K. Haldar “Depressant and anticonvulsant effect of methanol extract of Swietenia mahagoni in mice” Indian Journal of Pharmaceutical Education and Research (IJPER). 2010; 44(3). [IF-0.27]

11. S Das, Pallab K Haldar, G. Pramanik, Siva P Panda, S. Bera “Anticonvulsant activity of methanolic extract of Clerodendron infortunatum linn. in Swiss albino mice” Thai Journal of Pharmaceutical Science. 2010; 34: 129-133. [IF-0.13]

12. S Das, Pallab K Haldar, G. Pramanik, Siva P Panda, S. Bera “Evaluation of analgesic and anti-inflamatory activity of Diospyros cordifolia extract” African Journal of Traditional, Complementary and Alternative Medicine (AJTCAM). 2011; 8(1). [IF-0.70]

13. Pallab K. Haldar, Samit Bera, Siva P. Panda, Sanjib Bhattacharya, Nitai C.Chaulya, and Arup Mukherjee “Hepatoprotective activity of Cyperus tegetum rhizome against paracetamol-induced liver damage in rats” Journal of Complementary and Integrative Medicine (JCIM). 2011; 8(1): Article 22. [IF-0.40]

14. Pallab K. Haldar, Soumitra Adhikary , Siva P. Panda, Samit Bera, S Bhattacharya, Chandi C. Kandar “Hepatoprotective Efficacy of Swietenia mahagoni L. Jacq. (Meliaceae) bark against paracetamol-induced hepatic damage in rats. Indian Journal of Pharmaceutical Education and Research (IJPER). 2011; 45(2), Apr-Jun. [IF-0.27]

15. Sriparna KunduSen, M Gupta, Upal K Mazumder, Pallab K Haldar, Siva P Panda and S Bhattacharya “Exploration of in vivo antioxidant potential of Citrus maxima leaves against paracetamol induced hepatotoxicity in rats”. Pelagia Research Library, Der Pharmacia Sinica. 2011; 2(3): 156-163.

16. Sriparna KunduSen, M Gupta, Upal K Mazumder, Pallab K Haldar, S Bhattacharya, Siva P Panda “ Exploration of Anti-inflammatory potential of Citrus Limetta Risso and Citrus Maxima (J. Brum.) Merr”. Pharmacologyonline 1. 2011; 702-709.

Dr. GSN Koteswara Rao

1. Uma Sankar Gorla, M. Savithri, G.S.N. Koteswara Rao, Y. Niharika, P. Devi Sree Sathya, V. Harika. Evaluation of anti-inflammatory activity of hydroalcoholic extract of Ananas cosmosus fruit peel by HRBC membrane stabilization. Asian Journal of Pharmaceutical Research. 2018; 8(11): 33-35.

2. Bhagya Sree Molli, G.S.N. Koteswara Rao, B. Nagamani, P. Uma Devi. Formulation and evaluation of liquisolid compacts of aceclofenac. International Journal of Advances in Pharmacy and Biotechnology. 2017; 3(3): 1-13.

3. Vasavi I, Nagamani B, A Naga Mallika, I Indu, Aruna K, GSN Koteswara Rao, P Uma Devi. Comparison of antimicrobial activity and MIC of branded and generic forms of amoxicillin. International Journal of Advances in Pharmacy and Biotechnology. 2017; 3(2): 1-7.

4. Pondugula Sudhakara Reddy, GSN Koteswara Rao and KV Ramana Murthy. Formulation and evaluation of oral fast dissolving films of poorly soluble drug loperamide HCl using transcutol HP. International Journal of Advances in Pharmacy and Biotechnology. 2016; 2(2): 15-31.

5. Nagamani Bolla, V. Ramalingeswa Rao, GSN Koteswara Rao, T. Amruta Rai, P. Uma Devi. Formulation and characterization of theophylline hydrogels using freeze thaw and chemical polymerization methods. Indo American Journal of Pharmaceutical Research. 2016; 6(8): 6415-6424.

6. Uma Sankar Gorla, M. Savithri, P Sravani, P. Prudhviraj, M. Srimulya and GSN Koteswara Rao. In vitro alpha amylase inhibitory activity of crude ethanol extract of terminalia chebula leaves. International Journal of Advances in Pharmacy and Biotechnology. 2016; 2(2): 1-5.

7. GSN Koteswara Rao, KV Ramana Murthy , B Raj Kumar and B Roja Rani. Design, development and evaluation of controlled release floating drug delivery systems of verapamil HCl. International Journal of Pharma Sciences. 2015; 5(4): 1167-1173.

8. T Amrutha Rai, M Siva Prasanna, S Santosh Kumar, GSN Koteswara Rao, P Uma Devi. Enhancement of solubility and dissolution rate of poorly soluble irbesartan by polymorphism and solid dispersion techniques. International Journal of Advances in Pharmacy and Biotechnology. 2015; 1(1): 54-59.

9. GSN Koteswara Rao, KV Ramana Murthy, Aayisha Begum, B Roja Rani, Ch Ragha Naveen, B Raj Kumar, P Uma Devi. Formulation and evaluation of floating drug delivery systems of propranolol HCl using modified pulsincap technique. International Journal of Pharma Research and Review. 2014; 3(9): 15-22.

10. GSN Koteswara Rao, KV Ramana Murthy, GSV Subrahmanyam. Formulation and evaluation of floating capsule of propranolol HCl using modified pulsincap technique. International Journal of Pharmacy. 2014; 4(1): 465-472.

11. Vijaya Lakshmi N, GSN Koteswara Rao, B Roja Rani , K Manasa and V Bhavani Prasad. Development and validation of UV spectrophotometric method for the estimation of finasteride in tablets. International Journal of Pharma Sciences. 2013; 3(1): 123-125.

12. Nagamani Bolla, Rajan Raju.Ch, Sarat Chandra.K, G.S.N. Koteswara Rao, Uma Devi. P. Effect of natural polymers on controlled release of irbesartan from acacia and kernel loaded microspheres. International Journal of Inventions in Pharmaceutical Sciences. 2013; 1(4): 282-287.

13. Nagamani Bolla, Sarat Chandra, RajanRaju.CH, GSN Koteswara Rao, Uma Devi. P. Improvement of simvastatin solubility using natural polymers by solid dispersion technique. International Journal of Pharmaceutical Research and Biomedical Analysis. 2013; 2(2): 1-6.

Review articles

1. V. Bhavani Prasad, G.S.N. Koteswara Rao, B. Roja Rani, B. Raj Kumar, B. Sudhakar, P. Uma Devi and K.V. Ramana Murthy. In-vitro and in-vivo evaluation tests for floating drug delivery systems – a review. International Journal of Pharmacy. 2012; 2(3): 645-655.

2. Padmavathi Y., Koteswara Rao GSN, Vijaya Lakshmi N. Is obesity a hurdle in life?” – a review. The Indian Pharmacist. 2007; 6(62): 39-43.

Dr. D. Damayanthi

1. Damayanthi Dalu*, Satyavati Dhulipala and Suresh Akarapu. “Antihyperglycemic and Hypolipidemic activity of Leea indica”. International Journal of Bioassys. 2014. 3(3). 3155-59.

2. Damayanthi Dalu* and Satyavati Dhulipala. “Antidiabetic and Antihyperlipidemic activity of Alcoholic and Hydro-alcoholic extracts of Cocculus orbiculatus in Streptozotocin induced diabetic rats”. American Journal of Phytomedicine and Clinical Therapeutics. 2015. 3(3). 2321-48.

3. Damayanthi Dalu* and Satyavati Dhulipala. “Antidiabetic, Antihyperlipidemic and Antioxidant properties of Ventilago maderaspatana Gaertn. on Streptozotocin induced diabetic rats”. IOSR Journal of Pharmacy and Biological Sciences (IOSR-JPBS). 2015. 10(4). 50-59.

4. Damayanthi Dalu* and Satyavati Dhulipala. “Evaluation of possible mechanisms of three plants for blood glucose control in Diabetes”. Bangladesh Journal of Pharmacology. 2016. 11(2). 2321-48.

5. Damayanthi Dalu* and Satyavati Dhulipala. “Antihyperlipidemic activity of Hydroalcoholoic extracts of selected plants in high fat diet fed rats”. Advances in Pharmacology and Toxicology”. 2016. 17(1). 65-82.

6. Damayanthi Dalu* and Shankar Kalakotla. “Anticonvulsant Activity of Ethanolic Root Extract of C. sativus on experimental animals”. Advances in Pharmacology and Toxicology”. 2017. 18(1). 19-26.

7. Damayanthi Dalu* and Ganesh Y. “Formulation design and development of gastro retentive floating tablets of Atenolol” Journal of Pharmacy Research. 2017. 11(5). 479-484.

8. Damayanthi Dalu* and Swathi P. “Development and validation of RP-HPLC method for simultaneous estimation of Glimeperide, Metformin and Ramipril in pharmaceutical dosage forms” Journal of Pharmacy Research. 2017 11(5): 525-530.

9. Damayanthi Dalu* and Dr. K.V.S.R.G Prasad. “Evaluation of Antidiabetic and Antioxidant activities of N-Cinnamoyl Metformin Analogues” Research Journal of Pharmacology and Pharmacodynamics. 2017. 9(2). 1-7.

10. Damayanthi Dalu* and Ganesh Y. “Evaluation of Antihyperlipidemic and Antioxidant Activity of Inula racemosa Roots” Advances in Pharmacology and Toxicology” 2017. 19(2). 25-42.

11. Damayanthi Dalu* and Ganesh Y. Formulation Design and Development of Zolmitriptan ODT. Journal of Pharma Research. 2017. 6(10). 1-5.

12. Dr. Damayanthi Dalu*, Ravi Teja, Dr. V. Alagarsamy. Pharmacological Potential of Natural Flavonoid Diosmin as Immunomodulatory agent. Asian Journal of Pharmaceutical and Clinical Research. Accepted.

13. Dr. Damayanthi Dalu,* Dr. Satyavati Dhulipala, Jamunakar Kuncham. Antiobesity activity of Vitis Vinifera by Butter and Progesterone Induced Models. Journal of Pharmacy Research. Accepted.

14. Dr. Damayanthi Dalu. Anti ulcer activity of Leea Indica in Wistar Albino Rats. Archives of Nanomedicine. Accepted.

15. A Novel Spectroscopic Method for the simultaneous determination of Pregabilin and Vildagliptin in Synthetic Mixture. International Research Journal of Pharmacy. (Accepted)

Mr. A. Rajasekhar Reddy

1. Rajasekhar Reddy A, Prabhakar SA, Umasankar K, Bhagavan Raju M, Shireesha B, Design, Synthesis of Novel Thiophene series of Tacrines as possible Acetylcholine Esterase Inhibitors, J Chem (Under Review) (Hindawi Publishers)

2. Rajasekhar reddy Alavala, Prathusha Katahala, Ramyasree Boga, Umasankar Kulandaivelu, Shireesha Boyapati, Study of in vivo pharmacokinetic drug interactions of curcumin on tacrine by using RP-HPLC, Asian Journal of Pharmaceutical & Clinical Research, 2018, Vol 11, Issue 9, 1-7. IF – 0.49 (SCImago, SJR 2016)

https://innovareacademics.in/journals/index.php/ajpcr

3. Siva Prasad Panda, Rajasekhar reddy Alavala, Uttam Prasad Panigrahy, Evaluation of Anticancer activity of Cucumis Callosus against Ehrlich’s Ascites Carcinoma bearing mice, Asian Journal of Pharmaceutical & Clinical Research, 2018, Vol 11, Issue 10, 1-5. IF – 0.49 (SCImago, SJR 2016)

https://innovareacademics.in/journals/index.php/ajpcr

4. Rajasekhar Reddy Alavala, Ganapathi Thipparapu, Umasankar Kulaindaivelu, Bhagavan Raju Mantripragada, Shireesha Boyapati, Synthesis, in vitro and in silico screening of thienopyridines as acetyl cholinesterase inhibitors, Pharmaceutical Chemistry Journal 2018, (Accepted for Publication) IF – 0.49 (Thomson Reuters, 2016).

5. Guntupalli Chakravarthi, Alavala Rajasekhar Reddy, Maddi Ramayya, Assessment of Biological Activity and Comparison of UPLC and RP-HPLC Chromatographic Profles of Clausena excavata Burm.F. Pharmacogn J. 2017; 9(1): 98-101. IF-1.23 (Thomson Reuters, 2016). http://www.phcogj.com/article/248

6. G. Vijay Kumar, A. Rajasekhar Reddy, B. Vijaya Kumar, N. Devanna, Evaluation of Anticancer, Antioxidant and Possible Antimicrobial Properties of extracts of Momordica dioica roots, International Journal of Pharmaceutical Chemistry 2017; 07(05): 74-79. IF – 0.498 (GIF-2012).

https://ssjournals.com/index.php/ijpc/article/view/4174

7. Rajasekhar reddy Alavala, Umasankar Kulandaivelu, Pochaiah Bonagiri, Shireesha Boyapati*, Venkatesan Jayaprakash, Ananda Thangadurai Subramaniam, Synthesis and Antiviral activity of Dihydropyrimidine - Ciprofloxacin Mannich bases against various viral strains, Anti‐Infective Agents (formerly known as Anti-infective agents in Medicinal Chemistry), 2015, 13 (2), 154-165. IF-1.75 (Thomson Reuters, 2012). http://www.eurekaselect.com/136244

8. Umasankar Kulandaivelu*, Srikanth Challuri, Rajasekhar Reddy Alavala, Gomathi Periyasamy, Shireesha Boyapati, Synthesis, Antiglycating and Antioxidant activities of Triazolo hexahydroquinazolines, Journal of Pharmaceutical Chemistry, 2014, 2 (2), 6-11. http://www.vensel.org/index.php/jphchem/article/view/30

9. Umasankar Kulandaivelu*, Bhawatha Chawada, Shireesha Boyapati, Alavala Rajasekhar Reddy, Synthesis Antimicrobial and Anticancer Activity of 1-[(arylalkylidene) amino]-3-(4H-1,2,4-triazol-4-yl) thiourea, Journal of Pharmaceutical Chemistry, 2014, 1 (1), 5-9. http://www.vensel.org/index.php/jphchem/article/view/4

10. Prabhakar S. Achanta, Rajasekhar Reddy Alavala, Umasankar Kulandaivelu, Shireesha Boyapati*, Kundan Ingale, 2D-QSAR Studies of Tacrine Analogues for Acetylcholine Esterase (AChE) Inhibition using Multiple Linear Regression Analysis (2012), Letters in Drug Design & Discovery, 9, 858-866. IF- 0.96 (Thomson Reuters, 2012) http://www.eurekaselect.com/103277

11. Dinesh Pore, Ramesh Alli, Achanta Satish Chandra Prabhakar, Rajashekar Reddy Alavala, Umasankar Kulanthaivelu, Shireesha Boyapati*, Solid phase microwave assisted synthesis of curcumin analogs (2012), Letters in Organic Chemistry, 9, 447-450. IF- 0.82 (Thomson Reuters, 2012). http://www.eurekaselect.com/100011

Review article

1. Rajasekhar Reddy A, Dinesh P, Prabhakar A.S, Umasankar K, Shireesha B*, Bhagavan Raju M, A Comprehensive Review on SAR of Curcumin (2013), Mini Reviews in Medicinal Chemistry, 13, 1769-1777. IF- 3.2 (Thomson Reuters, 2014) http://www.eurekaselect.com/115475

Ms. G. Kalyani

1. B. Thangabalan, G. Kalyani, Addanki Yamini, G. Anil Kumar, Extractive Spectrophotometric Estimation of Duloxetine Hydrochloride in Pure and in Pharmaceutical Formulations, IIPI’s Journal of Analytical Chemistry, 2017; 9 (2):228-232.

2. Gade Kalyani, Venkateswarlu Guddeti, Durga Prasad, Galaba Prasanthi, Cardio Protective Effect Of Avena Sativa Linn., Against Isoproterenol Induced Myocardial Infarction In Male Sprague Dawley Rats, Adv. Pharmacol. Toxicol, Vol. 16 (3) 2015, 19-30.

3. Mayank Bhatt1, Paul Raj1, Kalyani G1, Dr.Thriveni Kc2, Dr.Vatsala Guruprasad2, Dr.Shivalinge Gowda Kp1. Evaluation Of Invivo Antioxidant Potentials Of Nutrislim Green Tea (Ayu-606)-An Ayurvedic Formulation In Ccl4 Induced Hepatoxicity In Rats, Indo American Journal Of Pharmaceutical Research, 2016, Vol 6, Issue 03, 2016.

4. Bhagyasree P*, Kalyani G, Neuroprotective Effect Of Anacardium Occidentale (Cashew Apple Fruit) Against Aluminum Toxicity: An Experimental Study On Cognitive Dysfunction And Biochemical Alterations In Rats, Asian J Pharm Clin Res, Vol 10, Issue 3, 2017, 164-169.

5. D. Ravi Sankar Reddy*, G. Kalyani1, K. Pradeep2, Md. Asif3, D. Kartheek4, M. Gangabhavani5, The Survey Of Cancer Patients In The Region Of Guntur: Based On Hospital Registry, International Journal Of Pharmacy And Pharmaceutical Sciences, Vol 9, Issue 2, 2017

Mr.K.Venkata Gopaiah

1. K.P.R. Chowdary, D. Uday Chandra, K.Venkata Gopaiah. Enhancement of dissolution rate and formulation development of pioglitazone-a BCS class II drug

2. K. Venkata Gopaiah. Formulation and characterization of colon specific drug delivery system of a matrix tablet, World journal of pharmaceutical and life sciences (WJPLS)

Ms. N. Sri Lakshmi

1. Konda Ravi Kumar, A.Suneetha, N.Srilakshmi. A validated LC Method for the Estimation of Rilpivirine in API and Pharmaceutical Dosage form. Journal of Pharmacy Research. 2012; 5(8):4434-4436.

PHARMACEUTICAL INVENTION AND ENTREPRENEURSHIP (PIE) CLUB

In accordance with the principles and policy of KL University for developing research and entrepreneurship skills in its stake holders, KLCP proposed a Research Club entitled “Pharmaceutical Invention and Entrepreneurship (PIE)” Club from KL college of Pharmacy at KLU for the benefit of Pharmacy graduates. The PIE club is administered and managed by the faculty and active student leaders from the Pharmacy college.

OBJECTIVES

The objectives of PIE club include,

1.Encouragement of creative and innovative thoughts in the students.

2.Identification of potential learners for research and innovation. Providing students’ in-depth understanding on their area of interest for learning and career development.

3.Inculcate research and entrepreneurship qualities in students.

4.Supporting the student ideas for innovation and research development.

5.Identification of potential ideas/projects viable for commercialization and startups development.

6.Facilitate the faculty and student interaction with industry and entrepreneurs.

7.Promote research consultancy activities in the department.

8.Attract the interest of entrepreneurs and facilitate campus recruitment.

9.Encourage the students to present and publish their ideas/concepts/projects in the form of review or research papers in national/international journals and conferences.

10.Encourage the student participation in public service activities by organizing community based extension activities.

11.Organize regular seminars/workshops/conferences/cultural events as a part of developing leadership qualities.

12.Develop a strong alumni network

ORGANIZATION

The PIE club is composed of four research groups which primarily perform their activities based on the below mentioned core areas of research for pharmaceutical innovation as identified by the faculty of pharmacy.

The group 1 (Drug Informatics) activities include

• Data collection and management in the form of an application for a Pharmaceutical or health care research.
• Development of applications for Patient medication and safety.
• Maintenance of a drug information database.
• Development of applications for pharmaceutical education and research.
• Design and development of in house software for QSAR and drug design studies.

The group 2 (Drug Manufacture) activities include

• Synthesis of new molecules and materials for drug discovery and development.
• Design of economic and efficient process for manufacture and purification of existing pharmaceutical substances.
• Preparation of new solid state forms for the pharmaceutical substances in the form of polymorphs/cocrystals/salts/hydrates etc.

The group 3 (Drug Delivery) activities include

• Design and development of innovative materials for drug delivery.
• Nanotechnology applications for drug delivery.
• Identification of new excipients for formulation development.
• Preparation of stable formulations with improved shelf life and efficacy.
• Organize events to promote industry-institute interaction.

The group 4 (Drug Naturals’) activities include

• Design and development of cosmetic products.
• Identification of natural herbs or ingredients for medical or cosmetic use.
• Design and maintenance of herbal garden.
• Preparation and evaluation of herbal formulations.
• Organize events to promote green chemistry, environment safety and personal hygiene.

The above groups are led by student coordinators under the guidance of a faculty member as mentor. The groups shall schedule meetings or interactive sessions with the mentors on regular basis to discuss on new ideas and also seek advice from KLEF Center for Innovation, Incubation And Entrepreneurship (CIIE) on resources required to convert the idea into a project/startup. In case of multi-disciplinary concepts the group may interact with the mentors of other discipline research groups in KLEF or take the assistance of an external resource person for the project execution. The group meeting minutes should be recorded and the club activities are displayed and regularly updated on the KLEFCP website.